Quyết định 2968/QĐ-BYT của Bộ Y tế về việc ban hành Hướng dẫn chẩn đoán và điều trị bệnh do vi rút Ebola

THE MINISTRY OF HEALTH

Decision No.2968/QD-BYT dated August 8, 2014 of the Ministry of Health guiding the diagnosis and treatment on disease caused by Ebola virus

Pursuant to the Government s Decree No. 63/2012/ND-CP dated August 31, 2012 defining the functions, tasks, powers and organizational structure of the Ministry of Health;

At the request of National Hospital of Tropical Diseases in Dispatch No. 409/BVNDTW dated August 08, 2014 providing Guidance on diagnostic and treatment of diseases caused by Ebola virus,

At the request of Medical Service Authority – the Ministry of Health,

DECIDES:

Article 1.Guidance on diagnosis and treatment of EBOLA virus diseases is issued with this Decision

Article 2.The Guidance shall be updated by the Council established under Decision No. 2929/QD-BYT dated August 07, 2014 of the Ministry of Health.

Article 3.This Decision takes effect on the signing date.

Article 4.Chief of the Ministry Office , Director of Medical Service Authority, Chief Inspector of the Ministry of Health, Departments of the Ministry of Health, Directors of hospitals affiliated to the Ministry of Health; Directors of Services of Health, heads of health authorities of other Ministries, heads of relevant units shall implement this Decision./.

For the Minister of Health

The Deputy Minister

Nguyen Thi Xuyen

GUIDANCE

DIAGNOSIS AND TREATMENT OF EBOLA VIRUS DISEASE

(Issued with the Decision No. 2968/QD-BYT dated August 08, 2014 of the Ministry of Health)

I. OVERVIEW

- Ebola virus disease (once called Ebola hemorrhagic fever) is a severe infectious disease with the fatality rate of up to 90%.  The disease is spread due to direct contact with tissues, blood, and bodily fluids of infected animals or humans, which could lead to an outbreak. The virus can be transmitted from human to human due to direct contact with bloods through wounds on the skin or mucous membranes, with bodily secretions and fluids (feces, urine, saliva, semen) of infected patients. People can also be infected Ebola when touching tools or belongings of infected patients such as clothing, linens, used needles.

- Ebola virus is one of three genera of Filoviridae family (filovirus). The other two are Marburgvirus and Cuevavirus. There are five species of ebolaviruses including:

+ Zaire ebolavirus (EBOV)

+ Sudan ebolavirus (SUDV)

+ Bundibugyo ebolavirus (BDBV)

+ Taï Forest ebolavirus (TAFV).

+ Reston ebolavirus (RESTV)

BDBV, EBOV, and SUDV have caused major epidemics in Africa, while RESTV and TAFV have never caused any epidemic.

- Targets of infection:

+ Hunters and people who live in the forest and come into contact with infected or infected dead animals (chimpanzees, apes, monkeys, antelopes, porcupines, fruit bats, etc.)

+ Family members of the patients or people having close contact with the infected patients

+ Undertakers and people having physical contact with the infected patients’ dead bodies.

+ Health workers who directly take care of infected patients

II. Symptoms

1. Clinical symptoms

- The incubation period varies between 2 and 21 days

- Common symptoms include:

+ Acute fever

+ Headache, muscle pain and weariness

+ Vomiting/nausea

+ Diarrhoea

+ Stomach pain

+ Conjunctivitis

- Rash: initially a dark red color as small as pins at hair follicles, then maculopapular rash with clear boundaries, and ultimately spread usually within the first week of infection.

- Haemorrhage symptoms

+ Black stool

+ Bleeding from injection sites

+ Coughing up blood, gingival bleeding

+ Blood in urine

+ Vaginal bleeding

2. Testing

- Blood formula: usually leucopenia, thrombocytopenia

- Increase in AST, ALT Creatinine and urea in blood may increase while the disease develops

- Coagulation: disseminated intravascular coagulation

- Urine test: proteinuria

- Test for causes: looking for antigens, antibodies, PCR, and virus culture Samples used for testing are blood that are preserved during transport medium and conformable with regulations on transport of blood-borne viruses.

IV. Ebola diagnosis

1. Suspected cases:

- Having an epidemiological link within 03 weeks before symptoms are observed:

+In direct contact with blood or bodily fluids of patients with confirmed or suspected Ebola virus disease

+ Living in or going to epidemic areas

+ In direct contact with bats, rats, or primates from epidemic areas

- - Having clinical symptoms of the disease

2. Confirmed cases:

Confirmed cases are suspected cases that are confirmed by positive PCR test.

3. Distinguishing diagnosis:

- Ebola virus disease must be distinguished from:

+ Dengue hemorrhagic fever

+ Streptococcus suis disease

+ Septicemia due to meningococcal disease

+ Septicemia and septic shock

+ Leptospira

+ Malaria with complications

V. Treatment

1. Principles of treatment

- No specific treatment exists; treatment is primarily supportive in nature.

- All suspected cases must undergo examination at hospitals, isolated, and sampled to test. Confirmed cases must be hospitalized and completely isolated.

2. Supportive treatment:

3. Cautions to some groups of patients

- Pregnant women face a very high risk of miscarriage/preterm delivery, and postpartum bleeding. The administration of oxytocin and postpartum intervention must comply with instruction in order to stop the bleeding.

- Breastfeeding women: Ebola virus can be transmitted through breast-milk. If the mother is suspected of having Ebola virus disease, the mother and her children must be hospitalized and isolated until they are treated. The mother should stop breastfeeding.

4. Criteria for discharge

A patient shall be discharged when:

- There is no fever for at least 3 days without signs of discharge of virus into the environment such as watery stool, coughing, bleeding, etc.

- Clinical symptoms are reduced, the patient’s condition is stable, and the patient can do everyday activities himself/herself.

- With regard to test results:

+ Negative PCR test (from the 3rdday after first symptoms)

+ If clinical symptoms are not reduced after 2 negative PCR tests that are carried out at an interval of 48 hours, one of which is carried out on the 3rdday or later from first symptoms, the patient may be taken care of outside the isolation ward.

VI. Prevention of Ebola virus prevention

1. Principles

- Takes measures to prevent and control contamination.

- Examine and isolate people suspected of Ebola infection.

- Medical facilities must take standard prevention measures and prevention according to routes of transmission.

- Provide information and reports the cases in accordance with Circular No. 48/2010/TT-BYT dated December 31, 2010 of the Ministry of Health.

2. Patients

- Isolate and treat patients at medical facilities in accordance with instructions of the Ministry of Health.

- Use personal protective equipment to minimize transmission.

- Avoid coming into contract with or moving patients; use personal protective equipment and specialized vehicles when it is necessary to move patients. Contaminated, dumped items, and excrements of patients must be treated and sterilized as prescribed.

- Ebola virus can be able to persist in semen and breast-milk, thus it is necessary to inform patients of how to prevent transmission after they are discharged.

- Dead bodies must be handled in accordance with Circular No. 02/2009/TT-BYT dated May 26, 2009 on guidelines for hygienic burial and cremation.

3. People in close contact:

- Wear personal protective equipment when taking care of patients (N95 facemask, safety glasses, hats, gloves, boots, clothing); wash hands with soap or antiseptic solutions after being in contact with patients.

- Avoid being contact with patients

- Practice proper personal hygiene, regularly wash hands with soap; use antiseptics for the nasal route.

- Make a list of people in close contact and monitor their health for 21 days from the last contact. Inform the people in contact of the signs of the disease, prevention and treatment so that they can avoid infection, monitor their own health, and recognize symptoms of Ebola virus diseases themselves. Notify the nearest medical facility if the symptoms are observed for timely diagnosis and treatment.

4. Transmission prevention at treatment facilities:

- Adhere to regulations on classifying, isolating, and treating patients, take measures for controlling contamination, provide personal protective equipment for health workers, caretakers, and other patients at the facility in accordance with instructions of the Ministry of Health.

5. Sterilization, environmental remediation, and waste treatment at hospitals:

Comply with the procedures of environmental remediation and waste treatment applied to isolated areas for highly infectious diseases.

6. Vaccines:

No vaccine against Ebola virus is currently available.